Group "Biomedical applications for proteins and enzymes. Pharma Biotechnology"


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Group is headed by Prof. N.I.Larionova

Research topics:

1) Development of drug delivery systems (proteins, oligonucleotides, antioxidants, anti-inflammatory and antineoplastic agents) with improved bioavalability.

  • Design of  polymer conjugates, polymer micelles, microparticles & microcapsules, nanoparticles, proteoliposomes.
  • Mucoadhesive films
  • in vitro & in vivo evaluation

2) Serine proteinases and their protein inhibitors of animal and plant origin. Isolation, kinetic and thermodynamic study of specificity.

Research cooperation:

In Russia:
  • Mendeleev University of Chemical Technology of Russia. Department  of Biotechnology. Associate Professor Babusenko E.S. (Protein encapsulation)
  • Mendeleev University of Chemical Technology of Russia. Professor Shtilman M.I. (Self-assembling systems based on amphiphilic polymers for medical use)
  • Pavlov State Medical University of Saint Petersburg. Professor Galebskaya L.V. (Complement system)
  • Lomonosov Moscow state academy of fine chemical technology. Professor Shvetz V.I., associate Professor Sorokoumova G.M. (Lipid- based protein delivery systems)
  • Department of Biology, Lomonosov Moscow State University. Dr. Selishcheva À.À. (Protein/Lipid interations)
  • A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University. Dr. Spiridiniva V.A. (Oligonucleotide delivery systems)
  • Scryabin Moscow Academy of Veterinary Medicine and Biotechnology, Professor Belousova R.V. (Antiviral action of protein preparations)
  • Russian Academy of  Postdiploma Education of Physicians. Member- Correspondent RAMS   Mashetova L. K.; Chair of Biochemistry, Professor Jarovaja G.À. (Biochemical motivation of using the ocular medicinal films)
  • Sechenov Moscow Medical Academy, Pharmaceutical Faculty. Associate Professor, Demina N.B. (Mucoadhesive drug delivery systems)
  • Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Professor  Rumsh L.D., Dr. Zamolodchikova T.S. (Regulation of duodenase activity by proreinase inhibitors) 
  • Universite Paris- Sud, Faculte de Pharmacie (France). Professor P. Couvreur, Professor D. Duchene, Dr.  R. Gref, Dr.  Ì. Ollivon (Nano- and microsystems for drug delivery)
  • Max-Planck Institute of Colloids and Interfaces, Golm/Potsdam (Germany). Professor H. Moehwald (Encapsulation of proteins in polyelectrolyte microparticles)
  • School of Pharmacy, University of Southern California, Los Angeles.(USÀ). Professor W.-C. Shen (Lipidization of proteins)

Offers for possible commercialization:

1. Biodegradable polymeric films for stomatology (Treatment of paradontitis, inflammatory and erosive- ulcerous processes in oral cavity)

2. Biologically active additive to food with anticarcinogenic and antitumor activity.

Mail address:
Department of Chemistry,
M.V.Lomonosov Moscow State University,
Moscow 119991, Russia

Phone: +7 495 939-3417
Fax: +7 495 939-5417
e-mail: nilar(at)
Last update – 01.02.2009

Selected papers